MUCOSA-LIKE DIFFERENTIATION OF HEAD AND NECK CANCER CELLS IS INDUCIBLE AND DRIVES THE EPIGENETIC LOSS OF CELL MALIGNANCY

Mucosa-like differentiation of head and neck cancer cells is inducible and drives the epigenetic loss of cell malignancy

Abstract Head and neck squamous cell carcinoma (HNSCC) is a highly malignant disease with high death rates that have remained substantially unaltered for decades.Therefore, new treatment approaches are urgently needed.Human papillomavirus-negative tumors harbor areas of terminally differentiated tissue that are characterized by cornification.Dissec

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